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Gut microbes that trace ancient human journeys

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The Indigenous African Hadza and South American Tsimane share gut microorganisms that shed light on human dispersals and microbial losses in industrialized societies.

By

  1. Carina M. Schlebusch

    1. Carina M. Schlebusch is in the Department of Organismal Biology, Uppsala University, SE-752 36 Uppsala, Sweden, and at SciLifeLab, Uppsala, and the Palaeo-Research Institute, University of Johannesburg, Johannesburg, South Africa.

  2. Maja Vukovikj

    1. Maja Vukovikj is in the Department of Organismal Biology, Uppsala University, SE-752 36 Uppsala, Sweden.

Humans have never travelled alone. When our ancestors spread out of Africa and across the other continents, they carried their microorganisms with them. Writing in Nature, Carter et al.1 compare the community of gut microbes (also known as the microbiota) from the Indigenous Hadza people of Tanzania with that of the Tsimane of Bolivia, whose populations diverged during human migrations that occurred tens of thousands of years ago. The authors report that, despite these dispersals, hundreds of microbial species are present in both groups. Furthermore, genetic differences between strains of the same microbial species in Hadza and Tsimane populations were broadly consistent with the timescale of prehistoric human migrations. Many of these shared microbes are now rare or missing in populations from industrialized regions.

doi: https://doi.org/10.1038/d41586-026-02969-5

References

  1. Carter, M. M. et al. Nature https://doi.org/10.1038/s41586-026-11106-1 (2026).

    Article  Google Scholar 

  2. Wibowo, M. C. et al. Nature 594, 234–239 (2021).

    Article  PubMed  Google Scholar 

  3. Bergström, A., Stringer, C., Hajdinjak, M., Scerri, E. M. L. & Skoglund, P. Nature 590, 229–237 (2021).

    Article  PubMed  Google Scholar 

  4. Linz, B. et al. Nature 445, 915–918 (2007).

    Article  PubMed  Google Scholar 

  5. Falush, D. et al. Science 299, 1582–1585 (2003).

    Article  PubMed  Google Scholar 

  6. Moodley, Y. et al. PLoS Pathog. 8, e1002693 (2012).

    Article  PubMed  Google Scholar 

  7. Schlebusch, C. M. et al. Science 358, 652–655 (2017).

    Article  PubMed  Google Scholar 

  8. Otani, S. et al. Gut Microbes 17, 2484385 (2025).

    Article  PubMed  Google Scholar 

  9. Sonnenburg, E. D. & Sonnenburg, J. L. Nature Rev. Microbiol. 17, 383–390 (2019).

    Article  PubMed  Google Scholar 

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Competing Interests

The authors declare no competing interests.

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