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Surprising protein links dietary restriction to increased lifespan in flies

Nature作者：Linda Partridge2026年9月23日正文已收录本站
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A fruit-fly protein thought only to store amino acids in fact responds to nutritional deficiency in both development and adulthood, resulting in lifespan extension.

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  1. Linda Partridge

    1. Linda Partridge is at the Institute of Healthy Ageing, University College London, London WC1E 6BT, UK, and in the Research Department of Genetics, Evolution and Environment, University College London.

Dietary restriction, which is a reduction in normal food intake short of malnutrition, can improve health and increase lifespan in a range of animals1 and can confer health benefits in humans2. Many systems in the body respond to nutrients and mediate the effects of dietary restriction3. Writing in Nature, Kosakamoto et al.4 and Wang et al.5 report experiments in the fruit fly Drosophila melanogaster that uncover molecular mechanisms underlying the effects of dietary restriction and raise intriguing questions.

doi: https://doi.org/10.1038/d41586-026-02774-0

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Competing Interests

The author declares no competing interests.

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