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Vast cellular gene-expression atlas could transform how scientists understand brain ageing and disease

Nature作者：Jennifer E. Below2026年9月23日正文已收录本站
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Single-nucleus RNA sequencing captures molecular changes in the prefrontal cortex across the lifespan and in health and disease.

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  1. Jennifer E. Below

    1. Jennifer E. Below is in the Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.

A collaborative project from the PsychAD Consortium has compiled RNA-expression (transcriptomic) data from millions of individual brain cells in samples provided by nearly 1,500 people. Writing in Nature, Yang et al.1, Lee et al.2 and Venkatesh et al.3 used this resource to identify a wealth of insights that could shift neuroscientists’ understanding of an area of the brain that shapes human personality and behaviours.

Nature 657, 885-887 (2026)

doi: https://doi.org/10.1038/d41586-026-02770-4

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Competing Interests

The author declares no competing interests.

  • Read the paper: Lifespan single-cell transcriptomic atlas of the human prefrontal cortex

  • Read the paper: Single-cell atlas of transcriptomic vulnerability across brain disorders

  • Read the paper: Single-nucleus transcriptome-wide association study of human brain disorders

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