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Scientific Reports (2026) Cite this article
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Abstract
Distinguishing high-risk women presenting with dyspnea during pregnancy remains clinically challenging. This study aimed to investigate the association between TDI-derived diastolic function parameters and inflammatory–metabolic indices, including the triglyceride–glucose (TyG) index, hemoglobin-to-RDW ratio (HRR), RDW-to-albumin ratio (RAR), and uric acid-to-albumin ratio (UAR), in pregnant women presenting with dyspnea. These indices reflect inflammatory and metabolic alterations that may influence cardiovascular adaptation during pregnancy. A total of 255 pregnant women were evaluated, including 130 with dyspnea and 125 controls. Demographic, laboratory, and echocardiographic parameters were recorded. TyG index, HRR, RAR, and UAR values were calculated and compared between groups. Receiver operating characteristic (ROC) analyses were performed to assess classification performance. Compared with the control group, pregnant women with dyspnea had significantly higher TyG index and UAR values, whereas HRR and RAR did not differ significantly. TDI-derived echocardiographic assessment revealed larger right atrial and right ventricular diameters, higher systolic pulmonary artery pressures, reduced septal and lateral E′ velocities, and increased E/e′ ratios in the dyspneic group. ROC analysis demonstrated that BNP, D-dimer, and UAR showed an acceptable discriminative performance for dyspnea (AUC = 0.747, 0.730, and 0.713, respectively), whereas the TyG index showed modest discriminative ability (AUC = 0.625). These findings suggest that TyG index and inflammatory ratios were associated with subtle statistical differences in selected tissue Doppler–derived parameters and may warrant further investigation in conjunction with clinical and echocardiographic assessment.
Subjects
Abbreviations
- TyG:
-
Triglyceride–glucose index
- HRR:
-
Hemoglobin-to-red cell distribution width ratio
- RAR:
-
Red cell distribution width-to-albumin ratio
- UAR:
-
Uric acid-to-albumin ratio
- TDI:
-
Tissue Doppler imaging
- E′:
-
Early diastolic myocardial velocity
- A′:
-
Late diastolic myocardial velocity
- E/e′:
-
Ratio of early mitral inflow velocity to early diastolic myocardial velocity
- BNP:
-
B-type natriuretic peptide
- sPAP:
-
Systolic pulmonary artery pressure
- MAP:
-
Mean arterial pressure
- BMI:
-
Body mass index
- CRP:
-
C-reactive protein
Funding
This study received no funding.
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The authors declare no competing interests.
Ethics approval
The study was approved by the Ethics Committee of Necmettin Erbakan University, Faculty of Medicine [Approval No: 2025/5628(23851), Date: 21/03/2025].
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Eyiol, H., Eyiol, A., Ertekin, B. et al. Tissue doppler–derived diastolic function parameters and their association with TyG index and inflammatory ratios in pregnant women with dyspnea. Sci Rep (2026). https://doi.org/10.1038/s41598-026-66506-0
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DOI: https://doi.org/10.1038/s41598-026-66506-0