Establishment and characterization of multiple myeloma cell lines from a single patient’s disease course immortalizes clonal heterogeneity

Nature作者:JE Wiedmeier-Nutor2026年8月12日正文已收录本站

Acknowledgements

We would like to acknowledge the patient who consented for this study. ChatGPT was used for grammar and language editing assistance only.

Funding

This work was supported in part by a grant from the NCI CPTAC program (U01CA271410) to AP, RF, and PLB and the Multiple Myeloma SPORE (P50 CA186781) for PLB and MC. The other authors declare no relevant funding.

Author information

Authors and Affiliations

  1. Division Hematology/Oncology, Mayo Clinic Cancer Center, Phoenix, AZ, USA

    JE Wiedmeier-Nutor, DL Riggs, CK Stein, S. Brown, Y. Shotts, JC Figueroa Aguirre, R. Fonseca, M. Chesi & PL Bergsagel

  2. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

    KK Mangalaparthi, RK Kandasamy & A. Pandey

  3. Department of Immunology, Mayo Clinic, Rochester, MN, USA

    RK Kandasamy

  4. Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA

    RK Kandasamy & K. Franke

  5. Division of Hematology, Mayo Clinic, Rochester, MN, USA

    RK Kandasamy

  6. Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Jackson, FL, USA

    YW Asmann

  7. Department of Cancer Biology, Mayo Clinic, Phoenix, AZ, USA

    E. Braggio

  8. Manipal Academy of Higher Education, Manipal, Karnataka, India

    A. Pandey

Authors

  1. JE Wiedmeier-Nutor
  2. DL Riggs
  3. CK Stein
  4. KK Mangalaparthi
  5. RK Kandasamy
  6. S. Brown
  7. K. Franke
  8. Y. Shotts
  9. JC Figueroa Aguirre
  10. YW Asmann
  11. E. Braggio
  12. R. Fonseca
  13. A. Pandey
  14. M. Chesi
  15. PL Bergsagel

Corresponding author

Correspondence to PL Bergsagel.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Supplemental Figures, 1, 2A, 2B, 2C, 3, 4, 5, 6, 7, 8, Supplemental Table 1. (download PPTX )

Supplemental Table 2. (download XLSX )

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wiedmeier-Nutor, J., Riggs, D., Stein, C. et al. Establishment and characterization of multiple myeloma cell lines from a single patient’s disease course immortalizes clonal heterogeneity. Blood Cancer J. (2026). https://doi.org/10.1038/s41408-026-01597-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1038/s41408-026-01597-6