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Increased urinary podocyte mRNA loss in term small for gestational age infants

Nature作者：Xingbo Mu2026年8月12日正文已收录本站
  • Article
  • Open access
  • Published:
  • Chao Ning1,2,3 na1,
  • Xueou Liu4,
  • Kong Li1,2,3,
  • Lulu Zhang1,2,3 &
  • …
  • Fangrui Ding1,2,3 

Scientific Reports (2026) Cite this article

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Abstract

Current studies have shown that low birth weight, preterm birth, intrauterine growth restriction, and being small for gestational age (SGA) are significant risk factors for the development of chronic kidney disease (CKD). The aim of this study was to incorporate SGA as an independent factor for consideration and investigate its impact on podocyte loss. Urine samples were collected from SGA infants and urinary podocin mRNA, urinary protein and urinary albumin were examined. Additionally, appropriate-for-gestational-age (AGA) infants matched by gestational age and preterm infants matched by birth weight were also included in the study. In conclusion, this study provides evidence that SGA is associated with an increased risk of podocyte depletion while confirming that preterm birth exerts an even more detrimental effect on podocyte loss compared to SGA.

Subjects

Acknowledgements

We acknowledge support from Tianjin Key Medical Discipline Construction Project (TJYXZDXK-3–029 C) . Thanks all nurses in department of neonatology of Tianjin Central Hospital of Obstetrics and Gynecology for collecting urine samples. In addition, Fangrui Ding thanks Lei Gao and Mo Ding for their care and support.

Funding

FD is sponsored by Tianjin Health Research Project (grant number: TJWJ2025XK009) and Tianjin Science and Technology Committee (21JCQNJC01650). LZ is sponsored by Tianjin Health Research Project (grant number: TJWJ2022QN087).

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Author notes

  1. These authors contributed equally: Xingbo Mu and Chao Ning.

Authors and Affiliations

  1. Department of Neonatology, Tianjin Central Hospital of Obstetrics and Gynecology, No. 156 Nan Kai San Ma Lu, Tianjin, 300000, China

    Xingbo Mu, Chao Ning, Kong Li, Lulu Zhang & Fangrui Ding

  2. Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin, China

    Xingbo Mu, Chao Ning, Kong Li, Lulu Zhang & Fangrui Ding

  3. Department of Neonatology, Nankai University Maternity Hospital, Tianjin, China

    Xingbo Mu, Chao Ning, Kong Li, Lulu Zhang & Fangrui Ding

  4. Research Institute of Obstetrics and Gynecology, Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin, China

    Xueou Liu

Authors

  1. Xingbo Mu
  2. Chao Ning
  3. Xueou Liu
  4. Kong Li
  5. Lulu Zhang
  6. Fangrui Ding

Corresponding author

Correspondence to Fangrui Ding.

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Competing interests

The authors declare no competing interests.

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Cite this article

Mu, X., Ning, C., Liu, X. et al. Increased urinary podocyte mRNA loss in term small for gestational age infants. Sci Rep (2026). https://doi.org/10.1038/s41598-026-65629-8

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  • DOI: https://doi.org/10.1038/s41598-026-65629-8

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