- RESEARCH BRIEFINGS
A subset of pancreatic cancer cells express the genes SERPINE1 or SERPINB2, which form a molecular mesh around them. This sticky matrix helps to retain immunosuppressive cells and exclude the immune cells that kill cancer cells. Disrupting this process in mice improves immune control of pancreatic tumours and sensitizes them to immunotherapy.
This is a summary of: Falcomatà, C. et al. A serpin–myeloid axis in pancreatic cancer heterogeneity and immune evasion. Nature https://doi.org/10.1038/s41586-026-11002-8 (2026).
doi: https://doi.org/10.1038/d41586-026-02703-1
‘Expert opinion’ and the figure are published under a CC BY 4.0 licence.
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