科技科学

Molecular computation that rolls energetically downhill

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A DNA-based computer that operates by relaxing to thermodynamic equilibrium has been demonstrated on ten molecular programs, which completed computations in as little as one minute. Some programs were rerun using distinct inputs up to 25 times and others were scaled up to 100-bit computations — although this slowed them down substantially.

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References

  1. Bennett, C. H. Int. J. Theor. Phys. 21, 905–940 (1982).

    Article  Google Scholar 

  2. Doty, D. et al. DNA Comput. Mol. Program. 10467, 249–266 (2017).

    Article  Google Scholar 

  3. Rothemund, P. W. K. Nature 440, 297–302 (2006).

    Article  Google Scholar 

  4. Winfree, E. Algorithmic Self-Assembly of DNA. PhD thesis, California Institute of Technology (1998).

  5. Wang, B., Chalk, C., Doty, D. & Soloveichik, D. Sci. Adv. 12, eadx3969 (2026).

    Google Scholar 

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