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HIV vaccines guide rare immune cells to make broadly neutralizing antibodies

Nature作者：S. Gnanakaran2026年8月11日正文已收录本站
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Three studies in non-human primates show that strategically designed vaccines could prime a population of B cells to produce effective antibodies against HIV.

By

  1. S. Gnanakaran

    1. S. Gnanakaran is in the Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA.

  2. Cynthia A. Derdeyn

    1. Cynthia A. Derdeyn is in the Department of Laboratory Medicine and Pathology, Washington National Biomedical Research Center, University of Washington, Seattle, Washington 98195, USA.

A vaccine that protects against HIV has remained out of reach since the virus was first isolated in the 1980s. Three studies published in Nature, from Guenaga et al.1, Marchitto et al.2 and Steichen et al.3, now represent an important preclinical advance towards this long-standing goal.

doi: https://doi.org/10.1038/d41586-026-02374-y

References

  1. Guenaga, J. et al. Nature 654, 777–785 (2026).

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  2. Marchitto, L. et al. Nature https://doi.org/10.1038/s41586-026-10838-4 (2026).

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  3. Steichen, J. M. et al. Nature https://doi.org/10.1038/s41586-026-10837-5 (2026).

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  4. Klasse, P. J., Sanders, R. W., Ward, A. B., Wilson, I. A. & Moore, J. P. Nature Rev Microbiol. 23, 734–752 (2025).

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  5. Haynes, B. F. et al. Nature Rev. Immunol. 23, 142–158 (2023).

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  6. Bale, S. et al. J. Virol. 91, 10.1128/JVI.00443-17 (2017).

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  7. Roark, R. S. et al. Science 371, eabd2638 (2021).

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  8. Steichen, J. M. et al. Science 384, eadj8321 (2024).

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  9. Korber, B. et al. PLoS Pathogens 22, e1013739 (2026).

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Competing Interests

C.A.D. has collaborated or co-authored publications with the following co-authors of the studies under discussion: Beatrice Hahn, Bette Korber, George Shaw, Guido Silvestri, Barton Haynes, Shane Crotty, Andrew Ward, Leigh Sewall, Christopher Cottrell, Diane Carnathan, William Schief, Frederic Bibollet-Ruche and Gunilla Karlsson Hedestam. S.G. has previously worked on NIH-funded projects with the following co-authors of the studies under discussion: Bette Korber, Kshitij Wagh and Barton Haynes.

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