CRISPR therapy cuts cholesterol for at least 12 months

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  • RESEARCH HIGHLIGHT

Small trial targeted liver proteins that play a part in the regulation of lipid levels.

A cutaway computer artwork showing the interior of an artery affected by yellow atherosclerosis, with red blood cells struggling to pass through.

Deposits of cholesterol (yellow; artist’s illustration) and other substances can clog up arteries. Credit: Springer Medizin/Science Photo Library

A single dose of a CRISPR gene-editing therapy reduces levels of harmful lipids — namely cholesterol and triglycerides — in the blood for at least one year1.

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doi: https://doi.org/10.1038/d41586-026-02740-w

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