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A practical recycling strategy for making thiophosphate molecules with enzymes

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An enzymatic platform for constructing the thiophosphate molecular motif without relying on large amounts of expensive reagents has been developed. The method lays the foundation for developing enzymatic cascades to synthesize thiophosphate-containing motifs in drug development.

This is a summary of: Wu, X. et al. An ATPγS recycling strategy for practical biocatalytic thiophosphorylation. Nature 656, 869–878 (2026).

doi: https://doi.org/10.1038/d41586-026-02482-9

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